ABSTRACT:

Research Article

Rp-Hplc Determination Of Raloxifene In Pharmaceuticl Tablets

P. VENKATA REDDY, B. SUDHA RANI,
G. SRINU BABU and J. V. L. N. SESHAGIRI RAO*
College of Pharmaceutical Sciences,
Andhra University. Visakhapatnam-530003, India.

A reverse phase HPLC method is developed for the determination of Raloxifene in pharmaceutical dosage forms. Chromatography was carried out on an inertsil C18 column using a mixture of acetonitrile and phosphate buffer (30:70 v/v) as the mobile phase at a flow rate of 1 mL/min. Detection was carried out at 290 nm .The retention time of the drug was 10.609 min. The method produced linear responses in the concentration range of 0.5-200 µg/mL of Raloxifene. The method was found to be applicable for determination of the drug in tablets.