ABSTRACT:

Research Article

A Note On The Estimation Of Moxifloxacin In Bulk And Pharmaceutical Formulations By Precipitation Reagents

K.V.S.PARASADA RAO, L.D.SRINIVAS, P. RAVI KUMAR, P.YESUPADAM AND G. PRABHAKAR*

Pharmaceutical and Food Analysis Division,
Department of Pharmaceutical Sciences Andhra University,
Visakhapatnam-530 003, India.

Simple spectrphotometric methods (A-C) for the assay of Moxifloxacin1 (MOX) based on the formation of its complexes with alkaloidal precipitants are described. MOX under so quantitative precipitation in the form of molecular complexes with iodine (I2, method A), ammonium molybdate (AM, method B) or phosphomolybdic acid (PMA, method C) when used in excess. In addition to precipitation reactions, color reactions have also been combined to estimate MOX. They are based on the color formation with either unreacted precipitant of the filtrate (I2) or released precipitant from the molecular complex (AM or PMA) with chromogenic reagent such as P-N-methyl amino phenol sulphate (PMAP)-sulphanilic acid (SAc) (for I2), potassium thiocyanate (for AM), cobalt nitrate (Co(II))-disodium salt of ethylene diamine tetra acetic acid (EDTA) complex (for PMA).