E-JOURNAL OF CHEMISTRY

Volume 3, No. 11, May-2006

An effective, eco-friendly method for iodination of  arenes is presented. The reaction of activated aromatics with a mixture of  sodium iodate and sodium sulphite  in the presence of hydrochloric acid  gives mono iodoarenes in high yields. 

A simple and sensitive spectrophotometric technique was developed for the determination of carbofuran in its formulations, water and grain samples. The method was based on the alkaline hydrolyzed product of carbofuran phenol interacted with diazonium salt of 4,4-azo-bis-3,3¢5,5¢-tetra bromo aniline. The maximum absorbance of the red coloured derivative was measured at 470 nm.  The beer’s law was obeyed in the concentration range of 0.1-16.0 mg/ ml.  The interference of the non target species were studied on the determination of carbofuran which increases the selectivity of the method. The present method was successfully applied for the determination of carbofuran in its formulations, water and grain samples.

Two new simple, sensitive, rapid and economical Spectrophotometric Methods (A and B) have been developed for the determination of Nelfinavir Mesylate in pharmaceutical bulk and tablet dosage form. The method A is based on the reaction of Nelfinavir with ferric chloride, potassium ferricyanide and hydrochloric acid to form a bluish green colored chromogen. The Method B is based on the formation of blood red colored chromogen with Ferric chloride and 1,10-phenanthroline. The absorbances of the chromogen were measured at their respective wavelength of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate

P. S. SYED SHABUDEEN, R. VENCKATESH and S. PATTABHI

A carbonaceous sorbent prepared from the indegeneous agricultural waste (which is facing solid waste disposal problem) Kapok Hull, by acid treatment was tested for its efficiency in removing basic dyes. Batch kinetic and isotherm experiments were conducted to determine the sorption and desorption of the Rhodamine-B from aqueous solution with activated carbon. The factors affecting the rate processes involved in the removal of dye for initial dye concentration, agitation time, and carbon dose and particle size have been studied at ambient temperature. The adsorption process followed first order rate kinetics. The first-order rate equation by Lagergren was tested on the kinetic data, and isotherm data was analyzed for possible agreement with the Langmuir and Freundlich adsorption isotherm equations. The intraparticle diffusion rate equation from which adsorption rate constants, diffusion rate constants and diffusion coefficients were determined. Intraparticle diffusion was found to be the rate-limiting step. The structural and morphological of activated carbon were characterized by XRD and SEM studies respectively.  

2–alkyl–6–bromo–3,1–benzoxazine–4–one (2) is synthesized by treating    p–Bromoanthranilic acid      and   Acetylechoride   or   Benzoylchloride.     Reaction   of  2–alkyl–6–bromo–3,1–benzoxazine–4–one (2). with  hydrazinehydrate  furnish  the  corresponding  3–Amino–2–methyl–6–bromoquinazoline–4(3H)–one (3)  which   on reaction   with   benzaldehyde   afford    N,N – arylidene derivative   (4).  Reaction of  4  with  various  diazonium salts yields 6–bromo–2–alkyl/aryl–3{[phenyl(phenyldiazenyl)methylene]amino}quinazolin–4(3H)–one .

2-Amino-4-(2-naphthalenyl) thiazole (1) was prepared from 2-acetylnapthalene. This amine on facile condensation with aromatic aldehydes afford Schiff Base/anils/azomethines(2a-h). These anils on cyclocondensation reaction with chloro acetyl chloride and thio glycolic acid (i.e. mercapto acetic acid) yields 2-azetidinones and 4-thiazolidinones respectively. The prepared compounds have been screened on some stains of bacteria.