ABSTRACT:
Research Article
Synthesis, Spectral Characterization and Evaluation
of Pharmacodynamic Activity of Copper and Nickel
Complexes of Ethambutol Dihydrochloride
M. MATHRUSRI ANNAPURNA*,
M.E. BHANOJI RAO and B.V.V. RAVI KUMAR
Department of Pharmaceutical Chemistry
Roland Institute of Pharmaceutical Sciences
Ambapua, Berhampur, Orissa-760010
Nickel and copper complexes of ethambutol [EB] were synthesized and characterized. On the basis of spectral and thermal data an octahedral geometry was assigned to the complexes with molecular formulae [Cu (C10 H24 N2 O2) 2 Cl2] 5H2O and [Ni (C10 H24 N2 O2) 2 Cl2] 2H2O. Coordination of ethylene diamine derivative to the metal ion was proposed. The anti-tubercular activity of the complexes was evaluated using Lowenstein–Jensen medium and MABA [Microplate Alamar Blue Assay] methods.
