ABSTRACT:
Research Article
Synthesis and Antifungal Activity of Azetidinone
and Thiazolidinones Derivatives of
2-Amino-6-(2-naphthalenyl)thiazolo[3,2-d]thiadiazole
K.H.PATEL and A.G.MEHTA*
Department of Chemistry
P.T.Science College
Surat, Gujarat, India
2-amino-6-(2-naphthalenyl)thiazolo[3,2-d]thiadiazole [1] was prepared by treatment of KCNS and Br2 on 2-Amino-4-(2-naphthalenyl) thiazole. This amine on facile condensation with aromatic aldehydes afford Schiff Base/anils/azomethines(2a-h). These anils on cyclocondensation reaction with chloro acetyl chloride and thio glycolic acid (i.e. mercapto acetic acid) afford 2- azetidinones and 4-thiazolidinones respectively. The prepared compounds have been screened on some stains of fungai.
