ABSTRACT:

Research Article

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid

Jin Tong-Shou *, Zhao Ying, Liu Li-Bin, Li Tong-shuang

College of Chemistry and Environmental Science,
Hebei University;
Hebei Province, Baoding 071002, P. R. China

An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction time.