ABSTRACT:

Research Article

Synthesis of Novel Schiff Base and Azetidinone Derivatives
and their Antibacterial Activity
KAMAL VASHI and H. B. NAIK
Department of Chemistry, Veer Narmad South Gujarat University,
Surat 395007, India.

A series of Compound 4-(2'-hydroxy-3'-chloro-5'-ethyl phen-1'-yl)-1-(4'-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2'-hydroxy-3'-chloro-5'-ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j has been prepared by the condensation of different substituted chalone derivatives 1 with p-toluidine 2. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Escherichia coli.