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E-JOURNAL OF CHEMISTRY |
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Volume 3, No. 12, July-2006 |
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| Title |
Synthesis, Characterization and Antimicrobial Activity of 5-(4-Methyl piperazinyl methylene)-8-hydroxy quinoline and its Various Metal Chelates |
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| Authors | I. J. PATEL and I. M. VOHRA | |
| Abstract | ||
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5-Chloromethyl-8-quinolinol was condensed with 4-methyl piperazine in presence of sodium bicarbonate. The resulting 5-(4-methyl piper-azinylmethylene)-8-quinolinol (MPQ) was characterized by elemental analysis and spectral studies. The transition metal chelates viz Cu+2, Ni+2, Co+2, Mn+2, Zn+2, Cd+2, and Fe+3 of MPQ were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. The antifungal activity of MPQ and its metal chelates was screened against various fungi. The results show that all these samples are good antifungal agents |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No. 110-116 | |
| Address |
P.
T. Science Sarvajanic College, Surat, Gujarat, INDIA. |
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| Title |
The Reaction of Aromatic Aldehydes and 1,3-Cyclohexanedione in Aqueous Media. |
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| Authors |
LIU LI-BIN, JIN TONG-SHOU , HAN LI-SHA, LI MENG, QI NA, LI TONG-SHUANG |
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| Abstract | ||
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The reaction of aromatic aldehyde and 1,3-cyclohexanedione in
aqueous media has been catalyzed by p-dodecylbenezenesulfonic acid (DBSA)
or sodium dodecyl sulfate (SDS) and yields two products: 9-aryl-1,
8-dioxooctahydroxanthene derivatives and 2,2’-arylmethylene bis(3-hydroxy- 2-cyclohexene-1-one). This
method provides several advantages such as good yield, simple work-up
procedure and environment friendly. |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No. 117-121 | |
| Address |
College
of Chemistry and Environmental Science, Hebei
University; Hebei Province, Baoding 071002, P. R. China. |
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| Title | Higher Order Elastic Constants, Gruneisen Parameters and Lattice Thermal Expansion of Lithium Niobate | |
| Authors | THRESIAMMA PHILIP, C. S. MENON and K. INDULEKHA | |
| Abstract | ||
The second and third-order elastic constants
and pressure derivatives of second- order elastic constants of trigonal
LiNbO3 (lithium niobate) have been obtained using the
deformation theory. The strain energy density estimated using finite strain
elasticity is compared with the strain dependent lattice energy density
obtained from the elastic continuum model approximation. The second-order
elastic constants and the non-vanishing third-order elastic constants along
with the pressure derivatives of trigonal LiNbO3 are obtained in
the present work. The second and third-order elastic constants are compared
with available experimental values. The second-order elastic constant
which corresponds to the
elastic stiffness along the basal plane of the crystal is less than
which corresponds to the
elastic stiffness tensor component along the c-axis of the crystal. The
pressure derivatives,
obtained in the present work, indicate that trigonal LiNbO3 is
compressible. The higher order elastic constants are used to find the
generalized Gruneisen parameters of the elastic waves propagating in
different directions in LiNbO3. The Brugger gammas are evaluated
and the low temperature limit of the Gruneisen gamma is obtained. The
results are compared with available reported values. |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No. 122-133 | |
| Address |
School of Pure and Applied Physics, Mahatma Gandhi University, Kottayam, Kerala, India-686560 |
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| Title |
Derivative Spectrophotometric Estimation of Ondansetron and Paracetamol |
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| Authors |
P. RAVI KUMAR, M. MURALI KRISHNA, P. BHANU PRAKASH, B. ANIL KUMAR and P. MADHUSUDHAN |
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| Abstract | ||
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A simple and reproducible spectrophotometric
method, requiring no prior separation, has been developed for the estimation
of ondansetron and paracetamol in combined dosage form.
First order derivative spectroscopy method is adopted to eliminate
spectral interference. The
methods obey Beer’s Law in concentration ranges employed for evaluation.
Ondansetron and paracetamol have lmax
at 302 nm and 246 nm respectively
in methanol. The results of
analysis have been validated statistically and recovery studies confirmed
the accuracy of the proposed method. |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No.134-136 | |
| Address |
Department
of Pharmaceutical Sciences, Andhra
University, Visakhapatnam-530 003. A.P., INDIA. |
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| Title |
Preparation and Antimicrobial Screening of Cu (II), Ni (II), Zn (II) Cd (II) Complexes |
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| Authors | R .M. DESAI , M. K. SHAH . and V. H. SHAH | |
| Abstract | ||
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The metal complexes of Ni(II), Cu(II), Zn(II)
Cd (II) with organic ligands viz
Hydrazine hydrate, 1,2-N,N′-Bisammonium
thiocarbamoyl ethane and 1,4-N,N′-Bisammonium thiocarbamoyl
benzene have been prepared. These ligands and metal complexes of
dithiocarbamates were screened for their antimicrobial activity against
various microbs. |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No.137-141 | |
| Address |
Chemical
Research Laboratory, Department of Chemistry Saurashtra University, Rajkot-360 005, India |
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| Title | Simultaneous Estimation of Domperidone and Pantoprazole in Solid Dosage Form by UV Spectrophotometry | |
| Authors |
P. RAVI KUMAR , P. BHANU PRAKASH, M. MURALI
KRISHNA, M. SANTHA YADAV and C. ASHA DEEPTHI |
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| Abstract | ||
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Domperidone is an antiemetic and pantoprazole
is an antiulcer drug. Simple,
precise, rapid and selective simultaneous equation and Q- analysis UV
spectrophotometric methods have been developed for the simultaneous
determination of domperidone and pantoprazole from combined tablet dosage
forms. The methods involve
solving of simultaneous equations and Q-value analysis based on measurement
absorptivity at 216, 287 and 290 nm respectively.
Linearity lies between 1-15 mcg/mL for domperidone and 0-50 mcg/mL
for pantoprazole. |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No.142-145 | |
| Address |
Department
of Pharmaceutical Sciences,Andhra University Visakhapatnam-530 003, A.P., India. |
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| Title |
Rapid Spectrophotometric Determination of Trace Amounts of Nitrate-Nitrogen using Dapsone and a-Naphthol |
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| Authors |
PADMARAJAIAH
NAGARAJA, JAINARA S. PRAKASH, BESAGARAHALLY L. BHASKARA, |
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| Abstract | ||
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A simple, rapid and sensitive spectrophotometric method has been
developed for the trace determination of nitrite using Dapsone and a-Naphthol.
The proposed method is based on the diazotization of Dapsone followed
by coupling with a-Naphthol
in sodium hydroxide medium to give an intense pink coloured azo dye.
The dye shows absorption maximum at 540 nm.
The molar absorptivity and Sandell’s sensitivity being 5.749 x 104
l mol-1 cm-1 and 0.24 ng cm-3 respectively.
Tolerance limit for interfering ions and complexing agents were
reported. Other analytical parameters and applications of the method for
analysis of tap water, lake water, and industrial effluents have been
investigated. |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No.146-153 | |
| Address |
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore – 570 006, India. |
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| Title |
Estimation of Some Antiviral Drugs Using Tpooo as Analytical Reagent |
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| Authors | P. VENKATA REDDY and B. SUDHA RANI | |
| Abstract | ||
| A simple and reproducible spectrophotometric method has been developed for the determination of two recent antiviral drugs namely Valacyclovir (drug A) and Famciclovir (drug B) in bulk and pharmaceutical dosage forms. The method is based on the extraction of the drugs into organic layer of the dye TPooo in presence of 0.1 N hydrochloric acid and the absorbances were measured at 490 nm. The method was optimized using eight parameters | ||
| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No.154-158 | |
| Address |
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam –530003, (A.P.), INDIA. |
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| Title | Infrared Irradiation Synthesis of Substituted 5-Oxo-1, 2, 3, 4, 5, 6, 7, 8-octahydroquinoline Derivatives under Solvent-free Conditions | |
| Authors |
SHU-XIANG WANG, SHAO-BO GUO, MING-ZHU GAO, JI-TAI LI1 and YUN-FEI DUAN |
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| Abstract | ||
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Infrared irradiation
promoted the synthesis of substituted 5-oxo-1, 2,
3, 4, 5, 6, 7, 8-octahydroquinoline derivatives. The condensations of 5, 5-dimethyl-1, 3-cyclohexane-dione, 1,
3-diaryl-2-propen-1-one and ammonium acetate in the absence of solvent under infrared irradiation for 3 h
gave the title compounds in
67.6%~86.5% yields |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No.159-163 | |
| Address |
College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei Province P. R. China. Luck Film Corporation, P.R. China. |
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| Title | Solvent-free Synthesis of Nitriles from Aldehydes Catalyzed by KF/Al2O3, Montmorillonite KSF and K10 | |
| Authors | LI-JUN LI, YING-XIA SONG, YAN-SU GAO,YAN-FENG LI and JIAN-FENG ZHANG | |
| Abstract | ||
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Multistep and one-pot conversion of
aldehydes to nitriles were carried out conveniently with out solvent using KF/Al2O3,
montmorillonite KSF and K10 as catalyst, under microwave irradiation. The
reactions are completed within 6-8 min to give satisfactory yields. KF/Al2O3
was more effective catalyst both in multistep procedure and one-pot
reaction. |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No.164-168 | |
| Address |
College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei Province P. R. China. |
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| Title |
Estimation of Ziprasidone Hydrochloride Monohydrate in Bulk and Capsules by Reverse Phase HPLC |
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| Authors |
B. SUDHA RANI* and P.VENKATA REDDY |
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| Abstract | ||
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A reverse phase HPLC method is described for
the determination of Ziprasidone HCl mono hydrate in bulk and pharmaceutical
dosage forms. Chromatography was carried out on an ODS C18 column using a
mixture of methanol and phosphate buffer (55:45v/v) as the mobile phase at a
flow rate of 1mL/min. Detection was carried out at 314nm. The retension time
of the drug was 4.522 min. The method produced linear responses in the
concentration range of 0.5-30 mg
/mL of Ziprasidone HCl mono hydrate.The method was found to be applicable
for determination of the drug in capsules. |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No.169-172 | |
| Address |
College
of Pharmaceutical Sciences, Andhra
University, Visakhapatnam-530003 (India). |
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| Title | Simple Spectrophotometric Methods for the Determination of Zidovudine in Pharmaceuticals Using Chloramine-T, Methylene Blue and Rhodamine-B as Reagents | |
| Authors | K BASAVAIAH* and U R ANIL KUMAR | |
| Abstract | ||
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Two new spectrophotometric methods are
proposed for the determination of zidovudine(ZDV) in pharmaceuticals. The
methods use chloramine-T (CAT) and two dyes, methylene blue and rhodamine-B,
as reagents and are based on adding of a known excess of CAT to ZDV in
hydrochloric acid medium followed by determination of residual oxidant by
reacting with a fixed amount of either methylene blue and measuring the
absorbance at 665 nm (Method A) or rhodamine B and measuring the absorbance
at 555 nm (Method B). In both methods, the amount of CAT reacted corresponds
to the amount of ZDV. The absorbance measured is found to increase linearly
with concentration of ZDV. Under the optimum conditions, ZDV could be
assayed in the concentration range 1.25-15.0 and 0.25-3.0 mg mL-1 by method A and method B, respectively. The apparent
molar absorptivities are calculated to be 7.7x103 and
5.6x104 L mol-1cm-1 for method A and
method B, respectively, and the corresponding Sandell sensitivity values are
0.035 and 0.005 µg cm-2. The limits of detection and
quantification are reported for both methods. Intra-day and inter-day
precision and accuracy of the developed methods were evaluated as per the
current ICH guidelines. The proposed methods can be readily utilized for
bulk drug and in pharmaceutical formulations. |
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| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No.173-181 | |
| Address |
Department
of Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India |
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| Title |
Inhibition of Mineralization of Urinary Stone Forming Minerals by Medicinal Plants |
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| Authors |
N. A. MOHAMED FAROOK*, P. MOZHIYARASI and R.
NALINI |
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| Abstract | ||
| The inhibition of mineralization of urinary stone forming minerals by medicinal plant i.e. chenopodium album linn, has been investigated. The inhibition efficiency was studied. Increased intake of fruits juice and seed extract of our plant would be helpful in urinary stone prophylaxis | ||
| Date of Online Publication | 21/07/2006 | |
| Full Text URL | E.J.Chem., Volume 3, No.12, Page No.182-185 | |
| Address |
P. G. Department of Chemistry & Biochemistry, Khadir
Mohideen College, Adirampattinam-614701, P.G.
Department of Biochemistry, Rabiammal Ahamed Maideen College, Thiruvarur, INDIA |
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